Publications by authors named "Carolina Fadoul de Brito"
Microb Pathog
October 2021
Article Synopsis
- Host genetics play a crucial role in determining an individual's resistance or susceptibility to active pulmonary tuberculosis (TB).
- A specific genetic variant, rs10818488 in the TRAF1/C5 gene, is linked to a higher risk of developing TB, with a significant association found in multibacillary cases leading to increased bacterial load in the lungs.
- The study indicates that a "loss-of-function" variant in TRAF1/C5 may lower the production of TNF-α, thereby increasing susceptibility to TB and affecting the clinical severity of the disease.
