Publications by authors named "Carolina Dias Carlos"
Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS mutations.
Letícia Ferro Leal Flávia Escremim de Paula Pedro De Marchi Luciano de Souza Viana Gustavo Dix Junqueira Pinto Carolina Dias Carlos Carlos Maciel da Silva
Sci Rep
March 2019
Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored.
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- EGF and EGFR are significant in lung cancer development, and a specific SNP in the EGF promoter (EGF+61 A>G) has been linked to cancer risk, but its role in lung cancer remains unclear.
- A study involving 669 lung cancer patients and 1104 controls in Brazil found no significant association between the EGF+61 A>G SNP and lung cancer risk, despite recognizing tobacco use and age as significant factors.
- The research determined that genotype frequencies in patients and controls did not show meaningful differences, concluding that EGF+61 A>G SNP is not a risk factor for lung cancer in the Brazilian population.
Recent studies have demonstrated the role of adenosine (ADO) in sickle-cell anemia (SCA). ADO is produced by CD39 and CD73 and converted to inosine by adenosine deaminase (ADA). We evaluated the effects of hydroxycarbamide (HU) treatment on the modulation of adenosine levels in SCA patients.
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