Publications by authors named "Carolina Costa Silva"

Article Synopsis
  • Prostate cancer typically progresses from hormone-sensitive forms to castration-resistant forms despite androgen deprivation therapy (ADT), prompting research into the role of T lymphocytes and gut microbiota in treatment effectiveness.
  • In mouse models, ADT improved thymic function and was less effective in mice lacking T lymphocytes or with depleted gut microbiota, showing connections between immune response and therapy outcomes.
  • Analysis of prostate cancer patients indicated that long-term ADT increased immune cell output and altered gut microbiota, with the potential for fecal transplants from healthy donors to improve treatment response, highlighting the need for addressing intestinal health in therapy.
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The reproductive success of a zoophilous plant species depends on biological interaction with pollinators, which involves both the provision and exploitation of flower resources. Currently, there is little information about how future climate change scenarios will impact interactions between plants and their flower visitors in the tropics. This study analyzes the effects of warming and two soil water conditions on interactions between the tropical forage legume species Stylosanthes capitata and its floral visitors during the flowering period.

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Tropical plant species are vulnerable to climate change and global warming. Since flowering is a critical factor for plant reproduction and seed-set, warming and elevated atmospheric carbon dioxide concentrations (eCO) are crucial climate change factors that can affect plant reproductive dynamics and flowering related events in the tropics. Using a combined free-air CO enrichment and a free-air temperature-controlled enhancement system, we investigate how warming (+2 °C above ambient, eT) and elevated [CO] (~600 ppm, eCO) affect the phenological pattern, plant-insect interactions, and outcrossing rates in the tropical legume forage species Stylosanthes capitata Vogel (Fabaceae).

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Background: The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria have been largely adopted in clinical practice. In a recent retrospective study, we assessed that the addition of the first site of metastatic disease to brain, bone, and liver improves prognostic stratification of patients with metastatic renal cell carcinoma (mRCC). Here, we performed an external validation in patients with mRCC.

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Hepatocellular carcinoma (HCC) is the fifth most common cancer, the third most common cause for cancer death in the world, a major cause of death in patients with chronic hepatitis C virus infection, and responsible for approximately one million deaths each year. Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of HCC. The incidence of HCC is expected to increase in the next two decades, largely due to hepatitis C infection and secondary cirrhosis, and detection of HCC at an early stage is critical for a favorable clinical outcome.

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