Publications by authors named "Carolina Carlos"
Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS mutations.
Sci Rep
March 2019
Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored.
View Article and Find Full Text PDFArticle Synopsis
- EGF and EGFR are significant in lung cancer development, and a specific SNP in the EGF promoter (EGF+61 A>G) has been linked to cancer risk, but its role in lung cancer remains unclear.
- A study involving 669 lung cancer patients and 1104 controls in Brazil found no significant association between the EGF+61 A>G SNP and lung cancer risk, despite recognizing tobacco use and age as significant factors.
- The research determined that genotype frequencies in patients and controls did not show meaningful differences, concluding that EGF+61 A>G SNP is not a risk factor for lung cancer in the Brazilian population.
An 8-yr-old male meerkat (Suricata suricatta) presented with sudden lethargy. A globular-shaped heart associated with pleural effusion on chest thoracic radiographs was consistent with congestive heart failure, and echocardiography was performed under general anesthesia. It revealed an Ebstein anomaly, with mild pericardial effusion and marked right heart enlargement.
View Article and Find Full Text PDFThe objective of the study was to determine whether the plasma concentrations of atrial and brain natriuretic peptides (ANP and BNP, respectively) could be reliable markers of cardiac alterations during occult cardiomyopathy in Golden Retriever Muscular Dystrophy (GRMD). Fifty Golden Retrievers without any clinical or radiographic sign of heart disease were included in this study (21 GRMD dogs and 29 controls). Controls and GRMD dogs were divided into 2 subgroups according to age (< and > or =12 months old, respectively).
View Article and Find Full Text PDFObjective: To quantify radial and longitudinal left ventricular free wall (LVFW) velocities in dogs during the preclinical phase of Golden Retriever muscular dystrophy (GRMD)-associated cardiomyopathy by use of tissue Doppler imaging (TDI).
Animals: 9 dogs with GRMD and 6 healthy control dogs.
Procedure: All dogs (< 3 years old) were examined via conventional echocardiography and 2-dimensional color TDI.
Objective: To determine left ventricular free wall (LVFW) motions and assess their intra- and interday variability via tissue Doppler imaging (TDI) in healthy awake and anesthetized dogs.
Animals: 6 healthy adult Beagles.
Procedure: n the first part of the study, 72 TDI examinations (36 radial and 36 longitudinal) were performed by the same observer on 4 days during a 2-week period in all dogs.
Objective: To report a technique for minimally invasive occlusion of patent ductus arteriosus (PDA) and outcome in 5 dogs.
Study Design: Clinical cases.
Animals: Five, 4-6-month-old, dogs with PDA.
Objective: To measure the radial and longitudinal velocities of several myocardial segments of the left ventricular wall by use of tissue Doppler imaging (TDI) in healthy cats and determine the repeatability and reproducibility of the technique.
Animals: 6 healthy cats.
Procedure: 72 TDI examinations were performed on 4 days by the same trained observer.