A Review of the Development of Multitarget Molecules against HIV-TB Coinfection Pathogens.

The human immunodeficiency virus (HIV) produces the pathologic basis of acquired immunodeficiency syndrome (AIDS). An increase in the viral load in the body leads to a decline in the number of T lymphocytes, compromising the patient's immune system. Some opportunistic diseases may result, such as tuberculosis (TB), which is the most common in seropositive patients.

Teaching Iramuteq for use in qualitative research according to YouTube videos: an exploratory-descriptive study.

Objectives: to identify the contents and characteristics of videos posted on YouTube that deal with Iramuteq software use as a tool to assist qualitative research and discuss the contribution of this social network to dissemination of knowledge, especially in the context of the COVID-19 pandemic.

Method: this is an exploratory-descriptive study with a qualitative approach, carried out with YouTube videos, collected in June 2021 and subjected to thematic analysis.

Results: a total of 43 videos on the researched topic were identified, with the majority (69.

COVID-19 pandemic and nursing week: analysis from software Iramuteq.

Objective: to analyze the themes of publications on the Federal Council of Nursing (Cofen) website during Nursing Week 2020.

Method: documentary, qualitative research, whose data sources were publications on the Cofen website from May 12 to 20, 2020. Data were processed by software IRAMUTEQ®, through the Descending Hierarchical Classification and analyzed under the historical materialism framework.

Contradicting perceptions of nursing teachers on the neoliberal context of labor.

Objectives: To identify and analyze the perceptions of nursing teachers on the new configurations of the job world and the repercussions for their labor activities.

Methods: Qualitative, descriptive, exploratory research, carried out at two federal nursing colleges in Rio de Janeiro. Data collection occurred with 27 nursing teachers, between May and June 2016, through semi-structured interviews.

Development of an Educational Protocol Based on a Nursing Team's Knowledge of Pulse Therapy in Adolescents in Brazil.

The aim of this study was to assess the knowledge of nursing teams that care for hospitalized adolescents undergoing glucocorticoid infusion and to develop an educational protocol for nursing care during pulse therapy. This descriptive, exploratory study with a qualitative approach was developed in a unit specializing in adolescent health at a university hospital in the state of Rio de Janeiro, Brazil. The instrument used for data collection was a semistructured interview conducted in a private room on the unit.

New Efavirenz Derivatives and 1,2,3-Triazolyl-phosphonates as Inhibitors of Reverse Transcriptase of HIV-1.

Background: According to the World Health Organization (WHO), the fight against Acquired Immunodeficiency Syndrome (AIDS) is still one of the most significant challenges facing humanity. Worldwide, it is estimated that 36.7 million people are infected by the Human Immunodeficiency Virus (HIV).

Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry.

Acquired immunodeficiency syndrome (AIDS) is a disease caused by human immunodeficiency virus (HIV) that affects individuals on all continents. In 1987, the antiretroviral therapy began increasing survival rates and improving the quality of life for patients. Efavirenz (EFV) is a drug widely used in the treatment of HIV-AIDS since 1998.

Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase.

Arginase is a glycosomal enzyme in Leishmania that is involved in polyamine and trypanothione biosynthesis. The central role of arginase in Leishmania (Leishmania) amazonensis was demonstrated by the generation of two mutants: one with an arginase lacking the glycosomal addressing signal and one in which the arginase-coding gene was knocked out. Both of these mutants exhibited decreased infectivity.

Novel 1,2,3-triazole derivatives for use against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain.

The purpose of this study was to prepare various 4-substituted N-phenyl-1,2,3-triazole derivatives using click chemistry. The derivatives were screened in vitro for antimicrobial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294) using the Alamar Blue susceptibility test. The activity was expressed as the minimum inhibitory concentration (MIC) in μg/mL (μM).