Publications by authors named "Carolina Bottura"
trans-Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production.
Renata M Martinez Felipe A Pinho-Ribeiro Vinicius S Steffen Carla V Caviglione Victor Fattori Carolina Bottura
Photochem Photobiol Sci
July 2017
Article Synopsis
- trans-Chalcone is a plant flavonoid with limited research on its effects in inflammation, yet it shows promise in reducing skin inflammation and oxidative stress caused by UV exposure in mice.
- The study found that trans-chalcone treatment decreased skin swelling, neutrophil activity, and a specific enzyme linked to inflammation, while also lowering levels of harmful cytokines.
- Although trans-chalcone did not directly mitigate oxidative stress in lab tests, its overall anti-inflammatory properties may make it a valuable treatment option for UV-induced skin issues.
Naringenin (NGN) exhibits anti-inflammatory and antioxidant activities, but it remains undetermined its topical actions against ultraviolet B (UVB)-induced inflammation and oxidative stress in vivo. The purpose of this study was to evaluate the physicochemical and functional antioxidant stability of NGN containing formulations, and the effects of selected NGN containing formulation on UVB irradiation-induced skin inflammation and oxidative damage in hairless mice. NGN presented ferric reducing power, ability to scavenge 2,2'-azinobis (3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) and hydroxyl radical, and inhibited iron-independent and dependent lipid peroxidation.
View Article and Find Full Text PDF