Publications by authors named "Carolina B Cabral"
This study investigated polycyclic aromatic hydrocarbons (PAHs) and organochlorine compounds such as polychlorinated biphenyls (PCBs) and DDT-related pesticides in surface sediments of Hooghly estuary and the Sundarban mangrove wetlands. Concentrations of ∑PAH, ∑PCB and ∑DDT ranged from 15.4 to 1731, not detected (nd) to 13.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the pharmacokinetics and distribution of the drug conjugate XMT-1001 and irinotecan (CPT-11) in mice with colon cancer.
- XMT-1001 was tested for its effectiveness in slowing tumor growth in mice, with various doses administered intravenously, while comparing it to CPT-11 in terms of plasma and tissue concentration.
- The results showed that XMT-1001 leads to higher levels of the active drug in the body and better tumor response than CPT-11, indicating its potential as a more effective treatment option.
Glutathione (GSH), an intracellular tripeptide that combats oxidative stress, must be continually replaced due to loss through conjugation and destruction. Previous methods, estimating the synthesis of GSH in vivo, used constant infusions of labeled amino acid precursors. We developed a new method based on incorporation of (2)H from orally supplied (2)H(2)O into stable C-H bonds on the tripeptide.
View Article and Find Full Text PDF