Publications by authors named "Carolina Arana Stanis Schmaltz"
Background: There are no specific recommendations for prevention of surgical site infection (SSI) caused by multidrug resistant Gram-negative bacilli (MDR-GNB). Our objective was to systematically review the literature evaluating the efficacy and safety of measures specifically designed to prevent MDR-GNB SSI.
Methods: We searched MEDLINE, EMBASE, CINAHL and LILACS databases up to February 18, 2020.
Introduction: Anemia is a common condition at tuberculosis diagnosis, and there is evidence that its prevalence is higher in patients with tuberculosis than in those infected with Mycobacterium tuberculosis and healthy controls. Information about anemia during tuberculosis diagnosis is still scarce in the Brazilian population. The aim of this study was to describe the prevalence of anemia in patients with tuberculosis cared for at a referral center and its association with clinical forms of tuberculosis and other characteristics of these patients.
View Article and Find Full Text PDFChanges in the NK Cell Repertoire Related to Initiation of TB Treatment and Onset of Immune Reconstitution Inflammatory Syndrome in TB/HIV Co-infected Patients in Rio de Janeiro, Brazil-ANRS 12274.
Front Immunol
September 2020
Article Synopsis
- Tuberculosis (TB) is a major health issue for individuals with HIV, being the leading cause of death, but combined antiretroviral therapy (cART) can help improve survival, despite issues like immune reconstitution inflammatory syndrome (IRIS).
- The study evaluated various types of innate lymphocytes in TB/HIV patients, including natural killer (NK) and γδ T cells, using flow cytometry, comparing them to patients with only TB or HIV and healthy controls.
- Findings showed significant changes in NK cell activation markers in TB/HIV patients, particularly those with IRIS, and highlighted an increased presence of certain γδ T cell subsets, indicating that HIV affects immune cell populations and responses during TB treatment.
Background: Rifamycins are a group of antibiotics mainly used in the treatment of tuberculosis (TB), however they interact with antiretroviral therapy (ART). Rifabutin allows more regimens options for concomitant imunodeficiency virus (HIV) treatment compared to rifampicin.
Objective: Compare the outcomes of TB-HIV co-infected patients who used rifampicin or rifabutin.
Background: Cutaneous tuberculosis (CTB) is a rare extrapulmonary form of tuberculosis (TB). Despite the increase in the number of cases of TB and HIV, few cases of CTB have been reported.
Objective: To describe CTB cases among patients with HIV infection from a cohort with tuberculosis.
Tuberculosis treatment has undergone recent changes in Brazil. . To assess whether favorable outcomes on tuberculosis therapy improved in recent years.
View Article and Find Full Text PDFObjective: Exposures to sharps injuries occurring in the community are relatively frequent. We describe characteristics of community sharp exposures reported in the city of Rio de Janeiro from 1997 to 2010.
Methods: A cross-sectional analysis of exposure reports to sharps in the community reported to a surveillance system, designed for health care workers, of the Municipal Health Department of Rio de Janeiro.
Article Synopsis
- The study aimed to identify factors influencing early mortality (within 3 months) in tuberculosis (TB) patients co-infected with HIV, comparing those who had previously started Highly Active Antiretroviral Therapy (HAART) and those who had not.
- Among 227 patients analyzed, 14 died within the first three months, with factors like the presence of disseminated TB and unknown CD4 count significantly increasing mortality rates in HAART naïve patients.
- Overall findings suggest that using HAART during TB treatment and having a CD4 count above 100 cells/mm3 decrease mortality risk, while those with a longer duration of TB symptoms showed higher mortality, particularly in patients who had previously started HA
Objective: To analyze tuberculosis treatment outcomes and their predictors.
Methods: This was a retrospective longitudinal cohort study involving tuberculosis patients treated between 2004 and 2006 at the Instituto de Pesquisa Evandro Chagas, in the city of Rio de Janeiro. We estimated adjusted risk ratios (ARRs) for the predictors of treatment outcomes.
Influence of HIV infection on mortality in a cohort of patients treated for tuberculosis in the context of wide access to HAART, in Rio de Janeiro, Brazil.
J Acquir Immune Defic Syndr
December 2009
Objective: To analyze the influence of HIV serostatus on mortality related to tuberculosis (TB) in the context of wide access to highly active antiretroviral therapy (HAART) in a middle-income country.
Methods: Prospective cohort study including patients who started antituberculous therapy between April 2000 and July 2005 at a referral center in Rio de Janeiro, Brazil.
Results: Two hundred seven patients were enrolled, 106 were seropositive for HIV.