Publications by authors named "Carolina Agra"
Article Synopsis
- - Glomus tumors (GT) are rare tumors that originate from glomus bodies in the skin and play a role in regulating body temperature, with most being benign but some showing aggressive and malignant behavior.
- - Malignant glomus tumors can spread and respond poorly to standard chemotherapy, but certain cases have a mutation (BRAF V600E) that offers a potential treatment target.
- - This report highlights a case of a metastatic glomangiosarcoma with the BRAF V600E mutation that showed significant improvement after being treated with encorafenib and binimetinib.
Article Synopsis
- Prognostic biomarkers are important for understanding sporadic desmoid tumors (DT) due to their unpredictable nature; this study focused on gene expression differences between DTs located in the thoracic versus abdominal wall.
- A retrospective analysis of 197 sporadic DT patients showed significant relationships between relapse-free survival (RFS) and factors like tumor size, location, and specific gene mutations, notably the CTNNB1 T41A and S45F mutations.
- Results suggest that tumors in the abdominal wall have a better prognosis compared to extra-abdominal locations, with distinct gene expression profiles influencing cancer pathways related to their behavior and outcomes.
Article Synopsis
- Microcystic adnexal carcinoma is a rare malignant tumor that affects sweat glands, primarily found in the deep dermis and known for being locally aggressive with a low chance of metastasis.
- A case study discussed a 46-year-old woman who had a slow-growing lesion on her upper lip, diagnosed as this type of carcinoma; she underwent surgery for removal and reconstruction.
- The tumor often presents as a solitary lesion on the central face of middle-aged Caucasian women, requires an incisional biopsy for accurate diagnosis, and has no established consensus on treatment or follow-up due to its rarity.
Introduction: Clear cell sarcoma (CCS) is a rare and aggressive soft tissue sarcoma. CCS is characterized by the translocation t(12;22) (q13;q12), involving the fusion of EWSR1 and ATF1 genes, and less frequently the fusion gene EWSR1-CREB1. Usually, CCSs are considered poorly responsive to conventional chemotherapy.
View Article and Find Full Text PDFRecurrent Pediatric Extranasopharyngeal Angiofibroma of the Epiglottis: Case Report.
Turk Arch Otorhinolaryngol
June 2023
Article Synopsis
Background: Solitary fibrous tumor is an unusual fibroblastic mesenchymal neoplasm typically described in the pleura. It may appear anywhere with a varied anatomic distribution and essentially it can develop from any soft tissue or visceral location. Its course is usually indolent and it rarely causes distant metastases, so it has a prolonged survival rate.
View Article and Find Full Text PDFIt is well known that the histology of normal pineal gland may resemble not only pineal tumors but also gliomas, owing to its cellularity which is much greater than that of normal white or gray matter. Our recent experience with a case in which part of a normal gland was submitted for intraoperative consultation, together with the scarcity of cytologic descriptions, led us to perform a cyto-histologic correlation study. In addition to the intraoperative case, we collected five pineal glands from consecutive adult autopsies.
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