Publications by authors named "Carolina Abrutzky"
Fast Acting, Dry Powder, Needle-Free, Intranasal Epinephrine Spray: A Promising Future Treatment for Anaphylaxis.
J Allergy Clin Immunol Pract
October 2023
Article Synopsis
- FMXIN002 is a needle-free nasal spray version of epinephrine designed to treat severe allergic reactions, aiming to overcome issues of incorrect use, cost, and shelf life associated with traditional autoinjectors.
- In a trial with 12 adults, FMXIN002 showed a quicker absorption time compared to the EpiPen, although the results were not statistically significant.
- Both treatments were well tolerated, with FMXIN002 exhibiting only mild, self-resolving side effects, while no adverse events were reported for the EpiPen.
Objective: To examine the pharmacokinetics and safety of FMXIN001, a new intranasal powder-based naloxone formulation, in comparison to Narcan® nasal liquid spray.
Methods: FMXIN001, was developed by blending drug microspheres with larger lactose monohydrate particles, that serve as diluent and carrier, as well as a disaggregating agent. Scanning electron microscopy and X-ray were used to characterize the formulation and in vitro deposition was investigated using a nasal cast.