The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation.

Background And Purpose: Therapeutic modification of the postischemic immune processes is a key target of current experimental stroke research. For successful translation into the clinical setting, experimental studies must account for the impact of different strokes on the immune system including susceptibility to infection. Herein, we characterize the impact of 3 ischemia models on systemic immunological and microbiological parameters.