3-Iodothyronamine Decreases Expression of Genes Involved in Iodide Metabolism in Mouse Thyroids and Inhibits Iodide Uptake in PCCL3 Thyrocytes.

Background: 3-Iodothyronamine (3-TAM) is an endogenous decarboxylated thyroid hormone (TH) metabolite. Pharmacological doses of 3-TAM decrease heart rate, body temperature, and metabolic rate in rodents-effects that are contrary to classic TH excess. Furthermore, a single dose of 3-TAM was shown to suppress the hypothalamic-pituitary-thyroid (HPT) axis in rats.

Thyronamines and Derivatives: Physiological Relevance, Pharmacological Actions, and Future Research Directions.

Thyronamines (3-TAM, TAM) are endogenous compounds probably derived from L-thyroxine or its intermediate metabolites. Combined activities of intestinal deiodinases and ornithine decarboxylase generate 3-TAM in vitro. Alternatively, 3-TAM might be formed by the thyroid gland and secreted into the blood.

3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling.

Most in vivo effects of 3-iodothyronamine (3-T1AM) have been thus far thought to be mediated by binding at the trace amine-associated receptor 1 (TAAR1). Inconsistently, the 3-T1AM-induced hypothermic effect still persists in Taar1 knockout mice, which suggests additional receptor targets. In support of this general assumption, it has previously been reported that 3-T1AM also binds to the α-2A-adrenergic receptor (ADRA2A), which modulates insulin secretion.

LC-MS/MS detection of thyroid hormone metabolites in tissue samples.

Evaluation of: Ackermans MT, Kettelarij-Haas Y, Boelen A, Endert E. Determination of thyroid hormones and their metabolites in tissue using SPE UPLC-tandem MS. Biomed.