Toward a Medical Gastric Bypass: Chronic Feeding Studies With Liraglutide + PYY Combination Therapy in Diet-Induced Obese Rats.

Background: Combination therapies of anorectic gut hormones partially mimic the beneficial effects of bariatric surgery. Thus far, the effects of a combined chronic systemic administration of Glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine 3-36 (PYY) have not been directly compared to Roux-en-Y gastric bypass (RYGB) in a standardized experimental setting.

Methods: High-fat diet (HFD)-induced obese male Wistar rats were randomized into six treatment groups: (1) RYGB, (2) sham-operation (shams), (3) liraglutide, (4) PYY, (5) PYY+liraglutide (6), saline.