Publications by authors named "Carolien Volleman"
Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with circulatory and/or pulmonary failure; however, the rate of complications remains high. ECMO induces systemic inflammation, which may activate and damage the endothelium, thereby causing edema and organ dysfunction. Advancing our understanding in this area is crucial for improving patient outcomes during ECMO.
View Article and Find Full Text PDFArticle Synopsis
- VA-ECMO (veno-arterial extracorporeal membrane oxygenation) is used to treat severe cardiac failure and can restore overall blood circulation, but its impact on small blood vessel function is still unclear.
- A systematic review of the literature (1215 studies sourced, 11 included) focused on how VA-ECMO affects microcirculation, measuring factors like small vessel density and blood flow.
- Initial findings suggest that microcirculatory function improves within hours for survivors of cardiac events post-ECMO, but this improvement levels off; more extensive research is needed to confirm these effects over time.
Background: Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these patients. The biological substrate behind these observations is unknown.
View Article and Find Full Text PDFPurpose: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).
Methods: An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made.