Overuse of analgesics can affect the fertility biomarker Anti-Müllerian Hormone in females. A translational study.

Background: Medication overuse headache is a prevalent secondary headache due to the overuse of analgesics, mainly over-the-counter analgesics. Over-the-counter analgesics have been associated with disrupted male endocrinology, while the effects on female endocrinology remain nearly unknown. The aim was to understand the effect of long-term analgesic exposure in females with medication overuse headache on Anti-Müllerian hormone, a surrogate measure of female fertility.

Treatment of medication overuse headache: Effect and predictors after 1 year-A randomized controlled trial.

Background: Combined withdrawal and early preventive medication was the most effective treatment for medication overuse headache (MOH) within the first 6 months in a previous study, but results from a longer follow-up period are lacking.

Objective: (1) To measure the efficacy at 1 year of three different treatment approaches to MOH; (2) to compare withdrawal and early preventives (W+P), preventives with potential withdrawal therapy after 6 months (P+pW), and withdrawal with delayed potential preventives (W+pP); and (3) to identify predictors of chronic headache after 1 year.

Methods: Patients with MOH and migraine and/or tension-type headache were randomly assigned to one of the three outpatient treatments.

Dependence-like behaviour in patients treated for medication overuse headache: A prospective open-label randomized controlled trial.

Background: Dependence-like behaviour may complicate withdrawal and increase risk of relapse of medication overuse headache (MOH). The most effective treatment for reducing dependence-like behaviour is unknown.

Objectives: To compare patient-reported outcomes among three treatment strategies for MOH.