Publications by authors named "Carole Seigel"
Article Synopsis
- The document aims to guide the use of opioids for managing pain in adults suffering from cancer or its treatment.
- A systematic review analyzed 31 systematic reviews and 16 randomized controlled trials, which showed that opioids effectively reduce moderate-to-severe cancer pain but have well-known side effects.
- Recommendations include prescribing opioids for cancer-related pain as needed and at the lowest effective dose, while monitoring for adverse effects and collaborating with specialists for patients with a substance use disorder.
Article Synopsis
- The purpose of the text is to raise awareness and provide guidance on managing immune-related adverse events (irAEs) for patients undergoing immune checkpoint inhibitor (ICPi) therapy.
- A diverse panel of medical experts conducted a systematic review of relevant literature from 2017 to 2021 to formulate updated management recommendations based on both evidence and expert consensus.
- Recommendations include continuing ICPi therapy with monitoring for mild toxicities, suspending treatment for moderate toxicities, and using corticosteroids for more severe cases, with a recommendation for permanent discontinuation for severe toxicities, except in specific controllable conditions.
Purpose: To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events (irAEs) in patients treated with chimeric antigen receptor (CAR) T-cell therapy.
Methods: A multidisciplinary panel of medical oncology, neurology, hematology, emergency medicine, nursing, trialists, and advocacy experts was convened to develop the guideline. Guideline development involved a systematic literature review and an informal consensus process.
Article Synopsis
- The text outlines guidance for managing dyspnea (shortness of breath) in adult patients with advanced cancer, highlighting the importance of both nonpharmacologic and pharmacologic interventions.
- The evidence was gathered from a systematic review that included randomized controlled trials, showing that while some nonpharmacologic treatments like airflow from fans can help, support for drugs is limited.
- It recommends a structured approach to treatment, starting with assessing and addressing reversible causes of dyspnea, and involving interdisciplinary palliative care, alongside potential treatments ranging from airflow interventions to opioids for severe cases.
Background: The Fred Hutchinson Cancer Research Center has engaged an External Stakeholder Advisory Group (ESAG) in the planning and implementation of the TrACER Study (S1415CD), a five-year pragmatic clinical trial assessing the effectiveness of a guideline-based colony stimulating factor standing order intervention. The trial is being conducted by SWOG through the National Cancer Institute Community Oncology Research Program in 45 clinics. The ESAG includes ten patient partners, two payers, two pharmacists, two guideline experts, four providers and one medical ethicist.
View Article and Find Full Text PDFPurpose The purpose of this new resource-stratified guideline is to provide expert guidance to clinicians and policymakers on implementing palliative care of patients with cancer and their caregivers in resource-constrained settings and is intended to complement the Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update of 2016. Methods ASCO convened a multidisciplinary, multinational panel of experts in medical oncology, family medicine, radiation oncology, hematology/oncology, palliative and/or hospice care, pain and/or symptom management, patient advocacy, public health, and health economics. Guideline development involved a systematic literature review, a modified ADAPTE process, and a formal consensus-based process with the Expert Panel and additional experts (consensus ratings group).
View Article and Find Full Text PDFPurpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process.
View Article and Find Full Text PDFPurpose To provide guidance to oncology clinicians on how to use effective communication to optimize the patient-clinician relationship, patient and clinician well-being, and family well-being. Methods ASCO convened a multidisciplinary panel of medical oncology, psychiatry, nursing, hospice and palliative medicine, communication skills, health disparities, and advocacy experts to produce recommendations. Guideline development involved a systematic review of the literature and a formal consensus process.
View Article and Find Full Text PDFPatients with cancer with multiple chronic conditions pose a unique challenge to how primary care and specialty care teams provide well-coordinated, patient-centered care. Effectiveness of these care teams in providing optimal health care depends on the extent to which they coordinate their goals and knowledge as components of a multiteam system (MTS). This article outlines challenges of care coordination in the context of an MTS, illustrated through the care experience of "Mr Fuentes," a patient in the Dallas County integrated safety-net system, Parkland.
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