Publications by authors named "Carole Drougard"
Article Synopsis
- Researchers identified a new spontaneous dystrophinopathy in Labrador Retrievers, called LRMD, which is phenotypically similar to the well-known Golden Retriever muscular dystrophy (GRMD) model used in studies for Duchenne muscular dystrophy (DMD).
- A colony of LRMD dogs was followed and assessed through various functional tests, revealing comparable results to those of GRMD dogs, indicating the relevance of LRMD for preclinical research.
- The study discovered a significant DNA mutation in the DMD gene associated with LRMD, providing insights that this model could help investigate additional genes that modify DMD outcomes.
Article Synopsis
- - The study investigates how human mesenchymal stem cells (hMSCs) respond to radiotherapy under different oxygen levels, focusing on their viability, cell cycle, and differentiation abilities post-irradiation.
- - Results showed that while hMSCs' radiosensitivity was unaffected by oxygen levels, radiation exposure led to a decrease in the S phase of the cell cycle and notable changes in gene expression related to osteogenesis and chondrogenesis.
- - Specifically, osteogenesis was disrupted by impaired matrix deposition and collagen expression, while chondrogenesis showed reduced expression of essential differentiation markers, indicating that radiation negatively impacts the formation and maintenance of hMSCs' functional characteristics.
Osteoarthritis (OA) is an irreversible pathology that causes a decrease in articular cartilage thickness, leading finally to the complete degradation of the affected joint. The low spontaneous repair capacity of cartilage prevents any restoration of the joint surface, making OA a major public health issue. Here, we developed an innovative combination of treatment conditions to improve the human chondrocyte phenotype before autologous chondrocyte implantation.
View Article and Find Full Text PDFThe GRMD (Golden retriever muscular dystrophy) dog has been widely used in pre-clinical trials targeting DMD (Duchenne muscular dystrophy), using in many cases a concurrent immune-suppressive treatment. The aim of this study is to assess if such a treatment could have an effect on the disease course of these animals. Seven GRMD dogs were treated with an association of cyclosporine A (immunosuppressive dosage) and prednisolone (2 mg/kg/d) during 7 months, from 2 to 9 months of age.
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