Aprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with a broad range of moderately emetogenic chemotherapies and tumor types: a randomized, double-blind study.

Purpose: Aprepitant was shown previously to be effective for prevention of chemotherapy-induced nausea and vomiting (CINV) with moderately emetogenic chemotherapy (MEC) in breast cancer patients receiving an anthracycline and cyclophosphamide (AC)-based regimen. This study assessed aprepitant in patients receiving a broad range of MEC regimens with a variety of tumor types.

Methods: This phase III, randomized, gender-stratified, double-blind trial enrolled patients with confirmed malignancies, naïve to MEC or highly emetogenic chemotherapy, who were scheduled to receive a single dose of at least one MEC agent.

Pierre Janet's addition to Charles-Hubert-Antoine Despine's "Old but very curious" Estelle L'Hardy monograph.

In the magisterial book The Discovery of the Unconscious, Ellenberger (1970) showed a keen appreciation for practitioners of many schools of therapy, including those who practiced animal magnetism (hypnotism). He credited Despine and Janet for their contributions to dynamic psychiatry and documented Janet's intellectual debt to Despine's successful magnetic treatment of 11-year-old Estelle's hysteria (dissociative disorder). No scholarship, however, has identified Janet's unique addition to Despine's 1838/1839 monograph--written decades before Janet's birth.

Characterization of reactive sites in supported catalysts by 51V/15N rotational echo double resonance NMR spectroscopy: formation of phenylimido groups at surface-bound oxovanadium sites.

Silica-supported oxovanadium groups were reacted in a gas-solid reaction with aniline at 175 degrees C. The reaction was clean as monitored in situ by UV-vis spectroscopy and resulted in the elimination of water as the principal product of the reaction and the disappearance of the terminal V=O stretch in the Raman spectrum. 15N MAS solid-state NMR spectroscopy showed only a single nitrogen-containing species on the surface.

The power of picture archiving and communication systems: strategic hospital considerations.

As healthcare information becomes more digitized, hospitals are adopting critical diagnostic tools to improve patient care decisions, while reducing errors and increasing overall efficiency. According to Radiology (2000), 75 percent of the imaging procedures performed in 1995 used devices that were not available in 1970. Today, imaging applications continue to move from research and development into common use each year With regard to digital imaging, Picture Archiving and Communication Systems (PACS) perhaps have changed radiology more than any other application in the past few decades.