Publications by authors named "Carola Fischer"
Purpose: Flow quantification using phase-contrast (PC) MRI is based on steady-state gradient echo (GRE) sequences and is hampered by spatially varying background phase offsets. The purpose of this work was to investigate the effect of steady-state disruptions during PC-MRI GRE sequences on these background phases. Based on these findings, a specific sequence and timing is suggested, and caution is expressed when using typical correction algorithms.
View Article and Find Full Text PDFArticle Synopsis
- A study developed an AI-based system for tracking heart valve motion using cardiac MRI to help diagnose heart dysfunction.
- The system utilizes two neural networks for locating and tracking key landmarks throughout the cardiac cycle, providing valuable motion parameters such as AVPD, MAPSE, and TAPSE.
- Results showed high accuracy in measuring motion parameters across a large dataset, indicating the system's effectiveness for analyzing heart valve function.
Article Synopsis
- Organotypic heart slices from mice are a valuable model for cardiac research due to the ease of genetic modification and experimental manipulation, but they typically degrade quickly in culture.
- Researchers established optimal conditions—like specific preload and medium agitation—to enhance the viability and function of these heart slices.
- With proper methods, heart slices maintained stable contractility for up to a week, preserving myofibril structure and essential gene expression, presenting a new avenue for cardiac function studies.
Purpose: Flow quantification by phase-contrast MRI is hampered by spatially varying background phase offsets. Correction performance by polynomial regression on stationary tissue may be affected by outliers such as wrap-around or constant flow. Therefore, we propose an alternative, M-estimate SAmple Consensus (MSAC) to reject outliers, and improve and fully automate background phase correction.
View Article and Find Full Text PDFTechnological advances in Magnetic Resonance Imaging (MRI) in terms of field strength and hybrid MR systems have led to improvements in tumor imaging in terms of anatomy and functionality. This review paper discusses the applications of such advances in the field of radiation oncology with regards to treatment planning, therapy guidance and monitoring tumor response and predicting outcome.
View Article and Find Full Text PDFThe original version of this Article incorrectly acknowledged Elisabeth Reiser and Rene Schramm as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.
View Article and Find Full Text PDFIn vitro models incorporating the complexity and function of adult human tissues are highly desired for translational research. Whilst vital slices of human myocardium approach these demands, their rapid degeneration in tissue culture precludes long-term experimentation. Here, we report preservation of structure and performance of human myocardium under conditions of physiological preload, compliance, and continuous excitation.
View Article and Find Full Text PDFPurpose: To evaluate if the use of ultrasound activated Al203 powder improved the fit especially of all-ceramic restorations.
Methods: 21 extracted teeth were prepared for 14 all-ceramic IPS Empress2 (IPS Empress2) restorations (four crowns, four partial crowns, two inlays, four veneers) and seven gold crowns (Degudent H). Each restoration was adjusted with a suspension of Al2O3 of 25 microm and 50 microm grit, respectively.