Publications by authors named "Carol W Gray"
The AP-1 transcription factor c-Jun is induced in axotomized neurons of the peripheral and central nervous systems, and in both cases upregulation of c-Jun expression has been correlated with axonal regeneration. More recently there has been interest in the c-Jun-related bZIP transcription factor, ATF3, and its function in neurons. ATF3 is also induced in nerve cells in response to axotomy and there is a correlation between increased ATF3 expression and upregulation of c-Jun in surviving neurons.
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- IAPs (inhibitor-of-apoptosis proteins) help regulate cell death by inhibiting caspases, which are enzymes that facilitate apoptosis.
- Reaper family proteins and Smac/DIABLO can bind to IAPs, preventing them from blocking caspases and promoting apoptosis in both flies and mammals.
- The study identified Omi/HtrA2 as a new protein that binds to the IAP XIAP, has a role in apoptosis, and is released from mitochondria during cell death, suggesting it functions similarly to the Reaper family proteins.