Moderately increased risks of Down's syndrome (1/51-1/270) identified on first trimester sequential screening: what do patients do with this information?

Objective: To document patient decisions after being informed of a first trimester sequential screen Down's syndrome risk between 1/51 and 1/270.

Setting: A database analysis of sequential screen results for patients seen in the Philadelphia, PA (USA) area between January 2006 and March 2008 was examined.

Methods: All patients with first trimester sequential screen Down's syndrome risks in the 1/51-1/270 range were identified.

Biochemical screening for aneuploidy in ovum donor pregnancies.

Objective: The purpose of this study was to compare the screening efficacy for aneuploidy detection in ovum donor pregnancies with the use of either the age of the ovum donor or the ovum recipient.

Study Design: Second-trimester biochemical screening for aneuploidy with alpha-fetoprotein, unconjugated estriol, and human chorionic gonadotropin was performed on maternal serum samples that were submitted prospectively from singleton ovum donor pregnancies. The calculation of aneuploidy risks were performed separately with the age of the ovum donor or the ovum recipient.