Publications by authors named "Carol Nassar"
Article Synopsis
- * The study utilized mouse models and specific knockout techniques to show that the disruption of B cell tolerance is dependent on the presence of the IFNα receptor and requires CD4+ T cells and Myd88 signaling.
- * Findings suggest that targeting IFNα signaling could be a potential therapeutic strategy for managing SLE by mitigating its effects on B cells and auto-antibody production.
Systemic Autoimmune Rheumatic Diseases (SARDs) are characterized by the production of anti-nuclear antibodies (ANAs). ANAs are also seen in healthy individuals and can be detected years before disease onset in SARD. Both the immunological changes that promote development of clinical symptoms in SARD and those that prevent autoimmunity in asymptomatic ANA individuals (ANA NS) remain largely unexplored.
View Article and Find Full Text PDF