Publications by authors named "Carol J Swanson"
Article Synopsis
- Access to high-quality human pancreatic islets is essential for diabetes research, and the IIDP has been a key provider for over 15 years.
- A study was conducted to determine the best shipping times for islets after isolation, testing various holding periods to optimize islet recovery and minimize loss.
- Results showed that longer preshipment holding times led to less islet loss during shipping, while islet function remained intact, indicating that giving islets recovery time is beneficial before shipment.
We have previously demonstrated that human T cells responding to porcine islets are primarily CD4+ and recognized porcine major histocompatibility complex class I molecules through the indirect pathway of antigen presentation. To determine whether this mechanism is responsible for rejection of adult porcine islets xenografts, porcine islets from adult pigs were transplanted under the kidney capsule of streptozotocin-treated CD4-knockout (KO), CD8-KO, Ig-KO and normal C57BL/6 mice. Islet xenografts were acutely rejected with similar kinetics when transplanted into normal C57BL/6 (MST=17.
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