Cytotoxic effect of venom on cancer cell lines: in vitro and in vivo studies.

Background: 's venom has shown immunomodulation of cytokines release in mice and selective cytotoxicity on cancer cells in a dose-dependent manner, highlighting an anticancer potential. Here, we extend these findings by elucidating the sensitivity of murine B16 skin melanoma and 3-MCA-induced murine fibrosarcoma cell lines to 's venom and its effect on tumor growth in vivo.

Methods: The toxicity of the venom on B16 and MCA cells was assessed using flow cytometry and xCELLigence assays.