Publications by authors named "Carol E Griffin"
The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and in vivo against Plasmodium falciparum malaria parasites. They may act by the inhibition of heme crystallization within the parasite digestive vacuole in a manner similar to chloroquine.
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- The antimalarial drug artemisinin and its derivatives feature a key endoperoxide structure that is highly effective against Plasmodium parasites, but its precise mechanism of action is still unclear.
- Research indicates that these drugs may work through iron-mediated reactions that create harmful metabolites, leading to damage in the parasite's cells.
- Studies showed that fluorescent trioxanes accumulate in specific areas within parasites, suggesting that artemisinin triggers lipid oxidation and affects parasite membrane integrity through interactions with heme and neutral lipids.