Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals.

Importance: The feasibility of core Infectious Diseases Society of America-recommended antimicrobial stewardship interventions in community hospitals is unknown.

Objective: To determine the feasibility and results of implementing 2 core stewardship intervention strategies in community hospitals.

Design, Setting, And Participants: Three-stage, multicenter, prospective nonrandomized clinical trial with crossover design.

Molecular biology of apolipoprotein E.

Apolipoprotein E, first identified 26 years ago as a serum protein that mediates extracellular cholesterol transport, is now known to regulate multiple additional metabolic pathways. Several clinically important disorders of the vasculature and brain are differentially caused, or modified, by the three isoforms of this protein. Apolipoprotein E was previously believed to traffic exclusively through binding cell surface receptors, endocytosis, and hydrolysis.