Salivary gland function in HIV-infected patients treated with highly active antiretroviral therapy (HAART).

Objective: This study was undertaken to determine if HAART alters salivary oral host defense in HIV(+) men.

Study Design: Whole, parotid, and submandibular/sublingual saliva was collected from 39 healthy men and 147 HIV(+) patients with mild to moderate immune dysfunction (69 treated with HAART [HAART(+)]; 78 not treated [HAART(-)]). Salivary flow rates, anticandidal activities, electrolytes, and antimicrobial/antifungal proteins were determined.