GWAS of 972 autologous stem cell recipients with multiple myeloma identifies 11 genetic variants associated with chemotherapy-induced oral mucositis.

Purpose: High-dose chemotherapy and autologous stem cell transplant (ASCT) to treat multiple myeloma (MM) and other cancers carries the risk of oral mucositis (OM) with sequelae including impaired nutritional and fluid intake, pain, and infectious complications. As a result of these problems, cancer treatment may have to be interrupted or delayed. In this study, we looked beyond OM's known risk factors of renal function and melphalan dose with a genome-wide association study (GWAS) to evaluate whether genetic variants in conjunction with clinical risk factors influence predisposition for OM.

Sleep measured by polysomnography in patients receiving high-dose chemotherapy for multiple myeloma prior to stem cell transplantation.

Purpose/objectives: To describe the objective sleep of patients receiving chemotherapy for multiple myeloma (MM) prior to stem cell transplantation.

Design: A descriptive study with repeated measures.

Setting: An international referral center in an urban area of the southern United States.

Review of current conceptual models and frameworks to guide transitions of care in older adults.

Older adults are at high risk for gaps in care as they move between health care providers and settings during the course of illness, such as following hospital discharge. These gaps in care may result in unnecessary re-hospitalization and even death. Nurses can assist older adults to achieve successful transitions of care by taking a systematic approach and individualizing care to meet patient and family health literacy, cognitive, and sensory needs.

Subjective sleep quality, objective sleep characteristics, insomnia symptom severity, and daytime sleepiness in women aged 50 and older with nonmetastatic breast cancer.

Purpose/objectives: To examine subjective sleep quality in women aged 50 and older as predicted by cancer status, age, number of comorbidities, and symptoms of depressed mood; and to describe objective sleep characteristics, insomnia symptom severity, and daytime sleepiness.

Design: Descriptive.

Setting: Urban university and private oncology clinics in the southern United States.

Sleep across chemotherapy treatment: a growing concern for women older than 50 with breast cancer.

Purpose/objectives: To conduct a metasynthesis of human sleep studies that included women aged 50 years and older with breast cancer across chemotherapy treatment.

Data Sources: English publications were searched with the terms sleep and breast cancer via Ovid, PubMed, and EBSCO-host databases. Human studies that used sleep-specific instruments published from January 1974-May 2009 were included.

Dietary soy intake and breast cancer risk.

Purpose/objectives: To conduct a metasynthesis of the literature on human studies of the relationship between dietary soy intake and breast cancer risk.

Data Sources: Publications in English reporting human studies were searched with the terms soy and breast cancer, using Ovid, PubMed, and EBSCO databases. Only human studies investigating the relationship of soy intake to breast cancer development in women published from January 1997 through June 2008 were included in the review.

Tailored biobehavioral interventions: a literature review and synthesis.

This article presents a metasynthesis of the literature from 1996 through 2005 on randomized clinical or controlled trials comparing effects of tailored interventions to those of control conditions or other interventions. A search was conducted for publications written in English using the terms "patient-centered interventions," "tailored interventions," and "individualized interventions," using Ovid and Elton B. Stephens Company (EBSCO) Host databases.

Research testing of tailored interventions.

The purpose of this article is to offer rationale to support the argument for research testing of tailored interventions. The individualization of nursing interventions is used as a basis for discussion of the emergent need to test tailored interventions at the research rather than practice level. Both justification of efficacy and feasibility support the research testing of tailored interventions, in support of an evolving nursing process.