Rapid progression of carotid stenosis was rare in a large integrated healthcare system during an eight-year period.

Objective: Few studies have evaluated the rapid progression of carotid stenosis on a large scale. We created a custom software algorithm to analyze an electronic medical record database to examine the natural progression of carotid stenosis, identify a subset of patients with rapid progression, and evaluate the specific patient risk factors associated with this rapid progression.

Methods: Patients in a large integrated healthcare system who had undergone two or more carotid ultrasound scans from August 2010 to August 2018 were identified.

Prognostic Factors for Arteriovenous Fistula Maturation.

Background: Recent studies have reported successful arteriovenous (AV) fistula maturation rates between 40% and 80%, with older age, distal fistula location, and small vein diameter associated with greater failure rates. Our objective is to determine if these findings are consistent with the outcomes at our institution.

Methods: A retrospective chart review was performed on patients who underwent upper extremity AV fistula creation at a single institution.

Prospective evaluation of treatment of open fractures: effect of time to irrigation and debridement.

Importance: The standard practice of irrigation and debridement (I&D) of open fractures within 6 hours of injury remains controversial.

Objective: To prospectively evaluate the effect of the time from injury to the initial I&D on infectious complications.

Design, Setting, And Participants: A total of 315 patients who were admitted to a level 1 trauma center with open extremity fractures from September 22, 2008, through June 21, 2011, were enrolled in a prospective observational study and followed up for 1 year after discharge (mean [SD] age, 33.

Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.

Diketo acids such as S-1360 (1A) and L-731,988 (2) are potent and selective inhibitors of HIV-1 integrase (IN). A plethora of diketo acid-containing compounds have been claimed in patent literature without disclosing much biological activities and synthetic details (reviewed in Neamati, N. Exp.