Publications by authors named "Carneiro M"

Article Synopsis
  • The study investigates how environmental and climate factors affect the spread of visceral leishmaniasis (VL) in Brazil's Doce River basin, aiming to enhance future surveillance and control efforts.
  • It utilizes ecological niche modeling, analyzing 855 VL cases from 2001-2018 to predict current and future disease distributions based on various climatic and environmental variables.
  • Key findings indicate that human activities and climate change could increase VL suitable areas by 7% by 2041 and 12% by 2080, emphasizing the need for improved vector control initiatives in the region.
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The non-invasive detection of crack/cocaine and other bioactive compounds from its pyrolysis in saliva can provide an alternative for drug analysis in forensic toxicology. Therefore, a highly sensitive, fast, reagent-free, and sustainable approach with a non-invasive specimen is relevant in public health. In this animal model study, we evaluated the effects of exposure to smoke crack cocaine on salivary flow, salivary gland weight, and salivary composition using Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy.

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Mercury (Hg) determination in marine sediment is an analytical challenge due to the toxicity of this element even at low concentrations (up to 130 μg kg in marine sediments) and complex matrices. Therefore, it is necessary to use analytical techniques that have high sensitivity, selectivity, and low limits of quantification (LoQ). In this study, two methods that require sample treatment and one method with direct sampling were studied.

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  • The Covid-19 pandemic adversely affected the management of other infectious diseases, especially in low and middle-income countries, leading to concerns about diseases like tuberculosis.
  • A matched case-control study compared Covid-19 effects in patients with prior tuberculosis against those without, using data from Brazilian hospitals over two years.
  • Results showed the tuberculosis group had higher rates of several comorbidities and medication usage but did not experience more severe outcomes like higher in-hospital mortality or need for intensive care compared to the control group.
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Dark Septate Endophytic (DSE) fungi can benefit plants by optimizing nutrient uptake, biosynthesis of phytohormones-like compounds, and stress relief such as toxic metals. The objective was to characterize in vitro 57 strains of the DSE Periconia macrospinosa isolated from sugarcane roots, indicating the most promising in solubilizing phosphate sources, growing in different metal and vinasse contents, and producing molecules related to indoleacetic acid (IAA). The strains were from the Embrapa Agrobiology Fungi Collection.

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Objective: To use hashtag and content analysis to determine the prevalence, authorship, and types of fertility-related and oncofertility information shared on Instagram in Brazil.

Methods: Eleven fertility-related hashtags were chosen according to https://www.tagsfinder.

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Context: Raddi is used in Brazilian folk medicine due to the wound healing and antiseptic properties of its bark, and its fruit are used as a condiment. However, the aerial parts of this plant have been studied and present some bioactive compounds as well.

Objectives: The aim of this study was to investigate the variation in volatile and non-volatile composition of leaves using untargeted metabolomics.

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  • The study aims to explore the social support networks of Amazonian women making decisions about planned home births in Pará, Brazil.
  • Conducting qualitative research with 20 women, interviews focused on experiences and knowledge shared among them, emphasizing the role of obstetric nurses during home births.
  • Findings highlight that strong social networks empower women to make informed choices about childbirth, while also suggesting the need for increased support from community and healthcare systems to enhance birth experiences.
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  • A study was conducted to determine the prevalence of HTLV-1 infection among transgender women (TGW) in Goiânia City, Brazil, revealing a knowledge gap in existing data on this demographic.
  • From a sample of 235 TGW, 1.3% tested positive for HTLV-1, with those positive reporting high-risk sexual behaviors and drug use.
  • The findings highlight the urgent need for health programs aimed at TGW to control HTLV-1 and other sexually transmitted infections due to their high-risk behaviors.
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Objectives: High sodium intake is a major risk factor for hypertension and renal diseases. Previous studies have shown that a suspension of ethanolic extract of Psidium guajava (guava) leaves (PsE) has antihypertensive effects in rats on a high-sodium diet (HSD), but some mechanisms to that remain unexplored. This study explored whether oral PsE treatment affects sodium handling by the intestine and alters the gut microbiome in HSD-fed rats.

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Parrots produce stunning plumage colors through unique pigments called psittacofulvins. However, the mechanism underlying their ability to generate a spectrum of vibrant yellows, reds, and greens remains enigmatic. We uncover a unifying chemical basis for a wide range of parrot plumage colors, which result from the selective deposition of red aldehyde- and yellow carboxyl-containing psittacofulvin molecules in developing feathers.

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Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL) responses against extracellular pathogens and tumors. This is achieved through a process known as cross-presentation (XP), and, despite its biological importance, the mechanism(s) driving XP remains unclear. Here, we show that a cDC-specific pore-forming protein called apolipoprotein L 7C (APOL7C) is up-regulated in response to innate immune stimuli and is recruited to phagosomes.

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Background: Proper analysis and interpretation of health care data can significantly improve patient outcomes by enhancing services and revealing the impacts of new technologies and treatments. Understanding the substantial impact of temporal shifts in these data is crucial. For example, COVID-19 vaccination initially lowered the mean age of at-risk patients and later changed the characteristics of those who died.

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In response to the COVID-19 pandemic, scientific authorities were routinely consulted by mainstream media outlets through interviews, statements and/or supporting images. In this framework, our goal in this study was to analyze the media representation of scientists in Brazil during the first year of this global public health crisis. To this end, we applied a research protocol and, using statistical techniques, quantitatively analyzed newscasts on the country's main TV news program, Jornal Nacional.

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This is the first systematic review and meta-analysis to estimate the prevalence of human T-lymphotropic virus 1 and 2 (HTLV-1 and 2) infections among immigrants and refugees worldwide. PubMed/MEDLINE, Scopus, EMBASE, Web of Science, and Virtual Health Library (VHL) databases were searched for studies published from their inception to 6 January 2023. A meta-analysis using a generalized linear mixed model with a random effect was performed for HTLV-1 and HTLV-2.

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Background: Acquired resistance and adverse effects are some of the challenges faced by thousands of Luminal A breast cancer patients under tamoxifen (TMX) treatment. Some authors associate the overexpression of HOXB7 with TMX resistance in this molecular subtype, and the knockdown of this gene could be an effective strategy to regain TMX sensitivity. Therefore, we used calcium phosphate hybrid nanoparticles (HNP) for the delivery of short interfering RNA molecule (siRNA) complementary to the HOXB7 gene and evaluated the RNA interference (RNAi) effects associated with TMX treatment in breast cancer in vivo.

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Plants are a source of valuable organic chemical compounds with complex structures rich in therapeutic activities. The encapsulation of compounds in nanostructured systems is an alternative to avoid limitations, such as instability and low solubility, and to promote therapeutic use. The objective of the present review was to summarize the data in the literature on the physicochemical characteristics, biomedical efficacy, and toxicity of nanostructures containing extracts and oils obtained from annatto ().

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Article Synopsis
  • Acromelanism is a type of albinism seen in various vertebrates, where mutations in the TYR gene affect melanin production, leading to specific hair or feather color patterns.* -
  • This study focused on identifying the genetic cause of the acromelanistic "pearl" canary and determined that a mutation in the TYR gene likely results in this phenotype.* -
  • The findings suggest that similar acromelanistic traits in other bird species may also be linked to mutations in the TYR gene, similar to what is observed in mammals.*
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Background: Evidence suggests that semi-facial respirators provide protection against contamination in high-risk environments, although the COVID-19 pandemic called for greater protection and viral inactivation capacity. Thus, the aim of this study was to investigate the efficacy of a novel semi-facial respirator containing chitosan nanoparticles, compared with a conventional N95 respirator on the incidence of laboratory-confirmed SARS-CoV-2 in healthcare professionals. The secondary outcomes were influenza infection, usability and comfort.

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  • Portugal has a lot of different plants and animals because of its unique geography and history, but these species are in danger from things like climate change and over-exploitation.
  • Researchers in Portugal are working together through a project called Biogenome Portugal to study and document biodiversity, which means looking closely at the genes of different species.
  • The goal is to create a library of genetic information to help protect endangered species and promote conservation efforts in Portugal, especially for unique plants and animals found only there.
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The current detection method for Chikungunya Virus (CHIKV) involves an invasive and costly molecular biology procedure as the gold standard diagnostic method. Consequently, the search for a non-invasive, more cost-effective, reagent-free, and sustainable method for the detection of CHIKV infection is imperative for public health. The portable Fourier-transform infrared coupled with Attenuated Total Reflection (ATR-FTIR) platform was applied to discriminate systemic diseases using saliva, however, the salivary diagnostic application in viral diseases is less explored.

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Amelogenesis imperfecta (AI) is a genetic disease characterized by poor formation of tooth enamel. AI occurs due to mutations, especially in AMEL, ENAM, KLK4, MMP20, and FAM83H, associated with changes in matrix proteins, matrix proteases, cell-matrix adhesion proteins, and transport proteins of enamel. Due to the wide variety of phenotypes, the diagnosis of AI is complex, requiring a genetic test to characterize it better.

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Background: Electroencephalography (EEG) is a promising tool for identifying the physiological biomarkers of fibromyalgia (FM). Evidence suggests differences in power band and density between individuals with FM and healthy controls. EEG changes appear to be associated with pain intensity; however, their relationship with the quality of pain has not been examined.

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