Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine.

Objective: To study iron deposition in red nucleus (RN), globus pallidus (GP), and periaqueductal gray matter (PAG) as a potential biomarker of chronic migraine (CM) and its association with levels of biomarkers related to migraine pathophysiology.

Methods: This case-control study included 112 patients with migraine (55 CM, 57 episodic migraine [EM]) and 25 headache-free controls. We analyzed iron deposition using 3T MRI and the NIH software platform ImageJ; we analyzed serum levels of markers of inflammation, endothelial dysfunction, and blood-brain barrier (BBB) disruption by ELISA in peripheral blood during interictal periods.

Morphological and functional changes of chronic pancreatitis in patients with dyspepsia: A prospective, observational, cross-sectional study.

Objective: Whether chronic pancreatitis (CP) may present with dyspepsia is controversial. We aimed at evaluating the frequency and risk factors of changes of CP in patients presenting with epigastric pain syndrome (EPS)-like symptoms.

Design: A prospective, observational, cross-sectional study was carried out in patients with EPS-like symptoms.

Acute spinal epidural hematoma and systemic mastocytosis.

Background: Systemic mastocytosis is a mast cell proliferative disorder affecting many organs that is rarely associated with internal bleeding.

Objective: To describe a case of spinal epidural hematoma in a patient with past medical history of urticaria pigmentosa and osteoporosis diagnosed with systemic mastocytosis.

Case Report: A 63-year-old woman with urticaria pigmentosa was admitted to hospital for severe back pain after minor trauma.