Publications by authors named "Carmen V Villabona"
Article Synopsis
- The study aims to evaluate the effectiveness of the Afirma Gene Expression Classifier (GEC) in analyzing thyroid nodules with atypia of undetermined significance (AUS) from fine-needle aspiration (FNA) cytology and to assess the accuracy of ultrasonography (USG) in predicting cancer risk in these cases.
- A total of 119 cases of thyroid nodules were studied, with findings showing a significant increase in the probability of malignancy in nodules that underwent GEC testing after an initial AUS diagnosis, particularly for those classified as AUS on a second biopsy (AUS-2).
- The results indicated that GEC testing had a higher positive predictive value after two AUS evaluations (91.4%) compared to
Objective: In this study, we aimed to determine whether preoperative thyroid fine-needle aspiration (FNA) in patients with multinodular goiter (MNG) and compressive symptoms influences the type of thyroid surgery performed, the incidence of recurrent thyroid cancer, or the need for successive surgery.
Methods: We retrospectively reviewed the charts of 431 patients who underwent thyroidectomy at our institution from 2008 to 2011. Patients who presented with compressive symptoms and no prior FNA at initial presentation were included in this study.
Objective: To define the effective time frame of adequate serum cortisol response to the short standard 250-microg adrenocorticotropic hormone stimulation test (ACTH-ST) after initiation of high-dose glucocorticoid therapy in order to assist in the diagnosis of adrenal insufficiency.
Methods: We performed an ACTH-ST at 4 different times in hospitalized patients, who had a documented intact hypothalamic-pituitary-adrenal axis and were receiving high-dose dexamethasone therapy for nonendocrine diseases, to determine the time until the serum cortisol response is compromised. The ACTH-ST was performed at the following time intervals after initiation of dexamethasone therapy - 24, 48, 72, and 96 hours.
Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis.
J Clin Endocrinol Metab
November 2008
Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial.
Objective: Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI.
Data Sources: We searched the PubMed database from 1966-2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators.