Effects of Infantile Hypophosphatasia on Human Dental Tissue.

Hypophosphatasia (HPP) is an inherited, systemic disorder, caused by loss-of-function variants of the ALPL gene encoding the enzyme tissue non-specific alkaline phosphatase (TNSALP). HPP is characterized by low serum TNSALP concentrations associated with defective bone mineralization and increased fracture risk. Dental manifestations have been reported as the exclusive feature (odontohypophosphatasia) and in combination with skeletal complications.

Retrospective investigation of the 3D effects of the Carriere Motion 3D appliance using model and cephalometric superimposition.

Objectives: Carriere Motion 3D™ appliance (CMA) represents a method for molar distalization and correction of class II malocclusion. The aim was to investigate the 3D effects of the CMA by superimposing digital models and cephalometric X-rays.

Materials And Methods: We retrospectively examined 16 patients treated with CMA in combination with class II elastics.

Mandibular condyle morphology among patients with mucopolysaccharidosis: An observational study of panoramic radiographs.

Background: Mucopolysaccharidoses (MPS) are a group of rare metabolic diseases characterized by a wide spectrum of symptoms including progressive condylar resorption.

Aim: The aim of this study was to quantify the severity of condylar involvement in MPS I individuals in comparison with a group of non-MPS individuals and to describe how condylar changes may vary among the different types of MPS.

Design: Fifty panoramic radiographs of MPS patients (13.