Publications by authors named "Carmen Torres-Zarate"
Orphan cytochromes P450 (CYP) are enzymes whose biological functions and substrates are unknown. However, the use of new experimental strategies has allowed obtaining more information about their relevance in the metabolism of endogenous and exogenous compounds. Likewise, the modulation of their expression and activity has been associated with pathogenesis and prognosis in different diseases.
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- The 5-year survival rate for patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is around 50%, often due to issues like tumor progression and resistance to chemotherapy.
- Researchers analyzed the expression of certain cytochrome P450 (CYP) enzymes in tumor tissue versus non-cancerous tissue in NRSTS patients using qPCR and Western blot methods.
- The study found significantly higher levels of CYP1B1, CYP2E1, and CYP3A4 in tumor tissues, suggesting their involvement in cancer development and the chemoresistance observed in these patients.
Background: Intratumoral up-regulation of genes coding for drug transporters and metabolizing enzymes, such as MDR1 and CYP3A4, after chemotherapy are linked to cancer drug resistance. However their expression in primary soft tissue sarcomas (STS) prior to drug treatment and their role in innate resistance remain unclear.
Objective: The aim of this study was characterize MDR1 and CYP3A4 expression pattern before to chemotherapy and its clinical implication in pediatric STS.