Publications by authors named "Carmen Silva Passos Lima"
Clin Transl Sci
March 2021
Article Synopsis
- The study investigates how variations in drug disposition genes relate to toxicities and treatment response in Brazilian women with epithelial ovarian cancer (EOC) undergoing chemotherapy.
- Researchers analyzed genetic variations in GST and ABCB1 genes in 112 women treated with carboplatin/paclitaxel, finding specific SNPs associated with reduced risk of anemia and dose delays, as well as increased risk of thrombocytopenia and neurotoxicity.
- The findings indicate that testing for these genetic variations could aid in predicting treatment-related side effects and improve clinical management for patients with EOC.
