Publications by authors named "Carmen Sevilla-Ortega"

Introduction: Chronic or uncontrolled activation of myeloid cells including monocytes, macrophages and dendritic cells (DCs) is a hallmark of immune-mediated inflammatory disorders. There is an urgent need for the development of novel drugs with the capacity to impair innate immune cell overactivation under inflammatory conditions. Compelling evidence pointed out cannabinoids as potential therapeutic tools with anti-inflammatory and immunomodulatory capacity.

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Article Synopsis
  • Innate immune cells undergo lasting metabolic and epigenetic changes after exposure to specific stimuli, enhancing their responses to pathogens in a process known as trained immunity.
  • Trained immunity-based vaccines (TIbV) can induce innate immune memory, potentially providing broader protection against various pathogens, yet their role in chronic allergic diseases remains unclear.
  • Recent studies indicate that environmental factors can cause innate immune cells to adopt pro-inflammatory roles in allergies, while certain vaccines may reprogram these cells to promote tolerance, suggesting new strategies for allergy prevention and treatment.
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Recurrent urinary tract infections (RUTIs) and recurrent vulvovaginal candidiasis (RVVCs) represent major healthcare problems with high socio-economic impact worldwide. Antibiotic and antifungal prophylaxis remain the gold standard treatments for RUTIs and RVVCs, contributing to the massive rise of antimicrobial resistance, microbiota alterations and co-infections. Therefore, the development of novel vaccine strategies for these infections are sorely needed.

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