Prognostic value of baseline and early response FDG-PET/CT in patients with refractory and relapsed aggressive B-cell lymphoma undergoing CAR-T cell therapy.

Purpose: Chimeric antigen receptor (CAR)-T cells are a viable treatment option for patients with relapsed or refractory (r/r) aggressive B-cell lymphomas. The prognosis of patients who relapse after CAR-T cell treatment is dismal and factors predicting outcomes need to be identified. Our aim was to assess the value of FDG-PET/CT in terms of predicting patient outcomes.

Gadoxetic acid enhanced MRI for differentiation of FNH and HCA: a single centre experience.

Objectives: Evaluation of enhancement characteristics of histopathologically confirmed focal nodular hyperplasias (FNHs) and hepatocellular adenomas (HCAs) with gadoxetic acid-enhanced MRI.

Methods: Sixty-eight patients with 115 histopathologically proven lesions (FNHs, n=44; HCAs, n=71) examined with gadoxetic acid-enhanced MRI were retrospectively enrolled (standard of reference: surgical resection, n=53 patients (lesions: FNHs, n=37; HCAs, n=53); biopsy, n=15 (lesions: FNHs, n=7; HCAs, n=18)). Two radiologists evaluated all MR images regarding morphological features as well as the vascular and hepatocyte-specific enhancement in consensus.

Size determination and response assessment of liver metastases with computed tomography--comparison of RECIST and volumetric algorithms.

Objective: To compare different three-dimensional volumetric algorithms (3D-algorithms) and RECIST for size measurement and response assessment in liver metastases from colorectal and pancreatic cancer.

Methods: The volumes of a total of 102 liver metastases in 45 patients (pancreatic cancer, n=22; colon cancer, n=23) were estimated using three volumetric methods (seeded region growing method, slice-based segmentation, threshold-based segmentation) and the RECIST 1.1 method with volume calculation based on the largest axial diameter.

Assessment of the cerebellar arteries with multidetector computed tomography angiography benefits from submillimeter slice thickness.

Purpose: To evaluate the accuracy of 64-row-multidetector computed tomography (MDCT) with different slice thickness (0.625 vs. 1.

[Chondromyxoid fibroma of the left maxillary and ethmoid sinuses].

Chondromyxoid fibroma is an infrequent bone tumour in the craniofacial bones and exceptional in the paranasal sinuses. This unusual location, its non-specific clinical manifestation and aggressive behaviour with local destruction and a high recurrence rate can complicate precise diagnosis and treatment.

[Laryngeal leiomyosarcoma].

Laryngeal leiomyosarcoma is a highly infrequent malignancy, with less than fifty reports in the scientific literature world-wide. Diagnosis is based on immunohistochemistry and, occasionally, on electron microscopy techniques, making it difficult to be done preoperatively. We report a new case of laryngeal leiomyosarcoma, with an up-to-date review of the differential diagnosis and the treatment strategy.

Epidemiological study of voice disorders among teaching professionals of La Rioja, Spain.

The purpose of the present study was to calculate the prevalence and incidence of voice disorders among teaching staff and find out the associated occupational risk factors. A case-control study was performed with 905 teachers, 579 cases and 326 controls; 492 were randomly selected and 413 volunteered. All teachers were asked to fill out a standard questionnaire.