Glucose intolerance in acromegaly is driven by low insulin secretion; results from an intravenous glucose tolerance test.

Purpose: Insulin sensitivity (S) and its role in glucose intolerance of acromegaly has been extensively evaluated. However, data on insulin secretion is limited. We aimed to assess stimulated insulin secretion using an intravenous glucose tolerance test (IVGTT) in active acromegaly.

Acromegaly versus hypogonadism: Bone fragility and evaluation.

Introduction: Osteopathy in patients with acromegaly is characterized by increased prevalence of vertebral fragility fractures (VF). However, the diagnostic criteria for osteoporosis are seldomly met in terms of bone mineral density (BMD), as patients with acromegaly frequently present normal BMD for age and gender.

Methodology: We performed a cross-sectional study on 71 patients with acromegaly and 75 patients with hypogonadism.