Publications by authors named "Carmen Moya-Lopez"
Article Synopsis
- - Gelatin is a widely used biopolymer in medicine because it's safe and doesn't trigger inflammation, and it can form Ionogels with ionic liquids (ILs) as cosolvents for better drug delivery.
- - The study focuses on using a specific IL, 1-ethyl-3-methylpyridinium perfluorobutanesulfonate (FIL), with fish gelatin to enhance the solubility of drugs like Doxorubicin while maintaining the mechanical and nanostructural properties of the material.
- - Controlled release mechanisms of Doxorubicin and Mithramycin from different Ionogel formulations were compared to traditional gelatin hydrogels, highlighting the importance of structural design for
The incessant developments in the pharmaceutical and biomedical fields, particularly, customised solutions for specific diseases with targeted therapeutic treatments, require the design of multicomponent materials with multifunctional capabilities. Biodegradable polymers offer a variety of tailored physicochemical properties minimising health adverse side effects at a low price and weight, which are ideal to design matrices for hybrid materials. PLAs emerge as an ideal candidate to develop novel materials as are endowed withcombined ambivalent performance parameters.
View Article and Find Full Text PDFA series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles featuring different nanostructures were designed to generate multifunctional drug delivery systems with tailored release rates required for personalized treatment approaches. The global conception of the systems was considered from the desired customization of the drug release while featuring the viscoelastic properties needed for their ease of storage and posterior local administration as well as their biocompatibility and cell growth capability for the successful administration at the biomolecular level. The hydrogel matrix offers the support to develop a direct thermal method to convert the typical kinetic trapped nanostructures afforded by the formulation method whilst avoiding the detrimental nanoparticle agglomeration that diminishes their therapeutic effect.
View Article and Find Full Text PDFStereo-diblock copolymers of high molecular weight polylactide (PLA) were synthetized by the one pot-sequential addition method assisted by a heteroscorpionate catalyst without the need of a co-initiator. The alkyl zinc organometallic heteroscorpionate derivative (Zn(Et)(κ-bpzteH)] (bpzteH = 2,2-bis(3,5-dimethylpyrazol-1-yl)-1-para-tolylethoxide) proved to assist in the mechanism of reaction following a coordination-insertion process. Kinetic studies along with the linear correlation between monomer and number average molecular weight (M) conversion, and the narrow polydispersities supported the truly living polymerization character of the initiator, whereas matrix-assisted laser desorption/Ionization-time of flight (MALDI-TOF) studies showed a very low order of transesterification.
View Article and Find Full Text PDFArticle Synopsis
- Hybrid nanocomposite materials were created by blending poly(l-lactic acid) (PLLA) with tungsten disulfide nanosheets (2D-WS) at varying amounts (0 to 1 wt%).
- The study explored how the addition of 2D-WS affected PLLA's crystallization rate and melting behavior, finding a surprising shift from reduced to increased crystallization with more nanosheets.
- Results revealed interesting double-melting peaks linked to the 2D-WS's influence on PLLA and suggested these nanocomposites could have valuable applications in various fields.