Inflammation and myocardial damage markers influence loss of residual renal function in peritoneal dialysis patients.

Background: Residual renal function (RRF) has been identified as the most important component in dialysis adequacy and has a strong effect on clinical outcomes. This justifies any effort in understanding the mechanism behind the preservation or decline in RRF. The aim of this study was to analyze the possible association of components of cardio-renal syndrome with the rate of decline in RRF.

Role of thyroid hormones and mir-208 in myocardial remodeling in 5/6 nephrectomized rats.

Background And Aims: Thyroid hormones exert important effects on heart remodeling through mir-208. The process may have a role in myocardial changes in chronic kidney disease where thyroid abnormalities are common. In this study the effect of T4 supplementation on left ventricle (LV) remodeling in 5/6 nephrectomized rats (5/6Nx) was analyzed.

De novo development of heart valve calcification in incident peritoneal dialysis patients.

Background And Aims: Cardiac valve calcification (VC) is a frequent complication in chronic kidney disease and is considered a risk factor for all-cause and cardiovascular mortality. However, little is known about the pathophysiology mechanisms that originate it and the factors associated with its development. We undertook this study to analyze the frequency and factors related to de novo development of mitral valve calcification (MVC) and aortic valve calcifications (AVC) in incident peritoneal dialysis (PD) patients.

Telomere length and type 2 diabetes in males, a premature aging syndrome.

Background: Increased telomere shortening has been demonstrated in several diseases including type 2 diabetes. However, it is not known whether telomere length changes during the course of type 2 diabetes.

Objective: To determine telomere length at different stages of type 2 diabetes, including early and late stages.

Association between telomere length and C-reactive protein and the development of coronary collateral circulation in patients with coronary artery disease.

Background: Coronary collateral circulation is a stabilizer factor in myocardial ischemia. We attempted to establish a link between collateral circulation, C-reactive protein (CRP), and telomere shortening.

Patients And Methods: A case-control study was performed in patients with (group A) and without (group B) coronary collaterals using coronariography.