Publications by authors named "Carmen Jimenez Lopez-Guarch"

Background And Objectives: Standardization of radiomic data acquisition protocols is still at a very early stage, revealing a strong need to work towards the definition of uniform image processing methodologies The aim of this study is to identify sources of variability in radiomic data derived from image discretization and resampling methodologies prior to image feature extraction. Furthermore, to identify robust potential image-based biomarkers for the early detection of cardiotoxicity.

Methods: Image post-acquisition processing, interpolation, and volume of interest (VOI) segmentation were performed.

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Introduction And Objectives: Chronic thromboembolic disease refers to the presence of chronic thrombotic pulmonary vascular thrombosis without pulmonary hypertension (PH) at rest but with exercise limitation after pulmonary embolism (PE). Our aim was to evaluate the hemodynamic response to exercise in these patients and its correlation with the values reached in cardiopulmonary exercise testing.

Methods: We included symptomatic patients with persistent pulmonary thrombosis after PE.

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Introduction And Objectives: The management of persistent moderate-severe tricuspid regurgitation (TR) in patients with chronic thromboembolic pulmonary hypertension after treatment with pulmonary endarterectomy (PEA) or balloon pulmonary angioplasty (BPA) is not well defined. This study aimed to analyze the progression and predictors of significant persistent postintervention TR and its prognostic impact.

Methods: This single-center observational study included 72 patients undergoing PEA and 20 who completed a BPA program with a previous diagnosis of chronic thromboembolic pulmonary hypertension and moderate-to-severe TR.

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We present the first imaging registry of the progressive isolation of an apical chamber of the right ventricle caused by the hypertrophy of the moderator band generated from the hemodynamic effect of a ventricular septal defect, leaving the apex of the right ventricle as an accessory chamber of the left ventricle. ().

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Acute idiopathic pericarditis (AIP) is a benign inflammatory condition associated with high recurrence rates. Non-steroidal anti-inflammatory drug (NSAIDs) and colchicine are the recommended therapies. Our objective was to systematically assess effects of pharmacological therapies on recurrences or treatment failure in patients with first and subsequent AIP episodes.

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Article Synopsis
  • The study investigates how truncating TTN variants (TTNtv) lead to dilated cardiomyopathy (DCM) by examining electrocardiograms (ECGs) and echocardiograms of TTNtv-DCM patients and their relatives.
  • Patients were categorized into five groups based on their left ventricular ejection fraction (LVEF), recovery status, and genetic factors, with analyses showing significant differences in T-index and abnormal T-wave prevalence among these groups.
  • The findings suggest that changes in repolarization patterns in ECGs can help identify patients with varying responses to treatment and highlight those at higher risk within the TTNtv-DCM spectrum.
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The Coronavirus Disease of 2019 (COVID-19) has supposed a global health emergency affecting millions of people, with particular severity in the elderly and patients with previous comorbidities, especially those with cardiovascular disease. Patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) could represent an especially vulnerable population because of the high mortality rates reported for respiratory infections. However, the number of COVID-19 cases reported among PAH and CTEPH patients is surprisingly low.

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Pulmonary artery aneurysm (PAA) is a common finding in patients with long-term pulmonary arterial hypertension (PAH). The influence of PAH severity in the development of PAA remains unclear. We sought to determine whether PAA development is related to PAH severity and whether treatment optimization based on risk profile estimation is effective to stop pulmonary artery (PA) enlargement.

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Detection of pulmonary artery aneurysms (PAA) in pulmonary arterial hypertension (PAH) is increasing. We sought to determine the frequency of PAA in a PAH cohort, variables related to its development and its prognostic impact. We conducted a retrospective analysis of PAH patients who underwent a computed tomography or magnetic resonance.

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Article Synopsis
  • - Pulmonary arterial hypertension (PAH) is a serious condition with high morbidity and mortality, characterized by increased pressure in the lungs and right heart dysfunction; this study aimed to analyze patient outcomes and prognostic factors at a national center over 30 years.
  • - The study included 379 PAH patients from 1984 to 2014, revealing trends like an increase in complex disease types and a significant rise in upfront combination therapy over the years, indicating improved treatment approaches.
  • - Key prognostic factors identified included age, sex, etiology, and various clinical variables, with a median survival of 9 years and survival rates decreasing over time; the findings stress the need for adaptable, multidisciplinary PAH care.
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Background: Pulmonary arterial hypertension (PAH) is common in patients with congenital heart disease (CHD). Although Eisenmenger syndrome may be on decline, other types of PAH-CHD are increasing and little is known on long-term outcome of this population. We report the PAH-CHD population of Spain via a national registry with focus on long-term survival.

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