Intra- and Extra-Hospital Dissemination of IMP-22-Producing e in Northern Portugal: The Breach of the Hospital Frontier Toward the Community.

The emergence of infections (and colonization) with producing carbapenemases is a threatening public health problem. In the last decades, we watched an isolated case becoming a brutal outbreak, a sporadic description becoming an endemic problem. The present study aims to highlight the dissemination of IMP-22-producing in the North of Portugal, through the phenotypic and genotypic characterization of isolates collected from hospitalized patients (=5) and out-patients of the emergency ward of the same acute care hospital (=2), and isolates responsible for the intestinal colonization of residents in a Long-Term Care Facility (=4).

Clinical Outcomes in Ring Avulsion Fingers and Systematic Review of the Literature.

Ring avulsions continue to be a challenge in reconstructive surgery. We conducted a retrospective study and reviewed all Urbaniak-Kay type IV degloving injuries replanted at our institution between 2011 and 2018. A systematic review of the literature was also conducted to assess the survival rates, functional, and sensibility outcomes.

Snake Venom Gland Organoids.

Wnt dependency and Lgr5 expression define multiple mammalian epithelial stem cell types. Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids that recapitulate essential features of the pertinent epithelium. Here, we establish long-term expanding venom gland organoids from several snake species.

Is the treatment of Enterobius vermicularis co-infection necessary to eradicate Dientamoeba fragilis infection?

Objectives: Dientamoeba fragilis is a pathogenic protozoan of the human gastrointestinal tract with a worldwide distribution, which has emerged as an important and misdiagnosed cause of chronic gastrointestinal illnesses such as diarrhea and 'irritable-bowel-like' gastrointestinal disease. Very little research has been conducted on the use of suitable antimicrobial compounds. Furthermore, higher rates of co-infection with Enterobius vermicularis have been described, suggesting that E.

[Energy expenditure prediction equations in burn patients; bibliographic review].

Introduction: The estimation of the caloric requirements of the burn patient is based on the measurement of his resting energy expenditure (REE) via indirect calorimetry, which is not available in all Burn Units, or its estimation by means of predictive equations.

Goals: we analyze the history and state of art of the use of REE predictive equations in burn patients, and determine their validity.

Methods: bibliographic review of the studies and reviews written in English and Spanish between 1989 and 2013.

Longitudinal maxillary growth in Down syndrome patients.

Objective: To assess maxillary growth in a sample of patients diagnosed with Down syndrome (DS).

Materials And Methods: The sample comprised 47 subjects (25 boys, 22 girls) with DS. All patients had at least two radiographs that showed the cranial base.

Cranial base growth in patients with Down syndrome: a longitudinal study.

Introduction: The purpose of this study was to assess the growth of the cranial base in a sample of patients diagnosed with Down syndrome (DS).

Methods: The sample comprised 47 subjects (25 boys, 22 girls) with DS. All patients had at least 2 x-rays that showed the cranial base.

Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14.

Natural Somatostatin-14 is a small cyclic neuropeptide hormone with broad inhibitory effects on endocrine secretions. Here we show that natural Somatostatin-14 spontaneously self-assembles in water and in 150 mM NaCl into liquid crystalline nanofibrils, which follow characteristic structural features of amyloid fibrils. These non-covalent highly stable structures are based on the Somatostatin native backbone conformation and are formed under non-denaturing conditions.

Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates.

Nuclear envelope (NE) formation during cell division in multicellular organisms is a central yet poorly understood biological process. We report that the conserved nucleoporin Nup155 has an essential function in NE formation in Caenorhabditis elegans embryos and in Xenopus laevis egg extracts. In vivo depletion of Nup155 led to failure of nuclear lamina formation and defects in chromosome segregation at anaphase.