Publications by authors named "Carmen Guaza Rodriguez"
The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.
Alessandra Bispo da Silva Paulo Lucas Cerqueira Coelho Jessika Alves Oliveira Amparo Monique Marylin Alves de Almeida Carneiro Julita Maria Pereira Borges Carmen Guaza Rodriguez
Chem Biol Interact
August 2017
Article Synopsis
- Rutin is a flavonoid found in many fruits and plants that has shown anti-inflammatory and antioxidant benefits, but its mechanisms on microglia (immune cells in the brain) were not well understood.
- In this study, rutin was tested on microglial cells both in their resting state and when stimulated with lipopolysaccharide (LPS), revealing that it promotes microglial proliferation and shifts their activation towards a protective M2 phenotype.
- The treatment with rutin also decreased pro-inflammatory cytokines and increased the production of the anti-inflammatory cytokine IL10, suggesting its potential as a therapeutic option for neurodegenerative diseases.