Publications by authors named "Carmen Fernandez-Merino"
Background And Aim: Few real-life studies have analyzed the glycemic response to nutrients in individuals without diabetes. We investigated the glycemic response to evening meals in relation to individual characteristics, nutrient components, and preprandial and postprandial routines.
Methods: A cross-sectional study of 489 individuals without diabetes from a randomly selected general adult population (310 women, median age 46 years, range 18-84 years) was conducted using a continuous glucose monitoring device for 7 days.
(1) Aim: To describe, in a general adult population, the serum glycome in relation to age in men and women, and investigate the association of glycome patterns with age-related comorbidity; (2) Methods: The serum glycome was studied by hydrophilic interaction chromatography with ultra-performance liquid chromatography in 1516 randomly selected adults (55.3% women; age range 18-91 years). Covariates included lifestyle factors, metabolic disorders, inflammatory markers, and an index of comorbidity.
View Article and Find Full Text PDFContinuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains limited. The present work examines the reproducibility of the results provided by a CGM system in a random sample of a free-living adult population, from a functional data analysis approach.
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- The study aimed to explore how time range metrics from continuous glucose monitoring could predict the risk of developing type 2 diabetes (T2D) in a group of 499 non-diabetic individuals over five years.
- Out of the participants, 22 developed T2D, with the analysis showing that 'time above range' (plasma glucose >140 mg/dL) significantly increased the risk of diabetes, indicating an odds ratio of 1.06 after adjusting for various factors.
- The findings suggest that tracking 'time above range' can provide valuable insights beyond traditional measures like glycated hemoglobin for identifying individuals at high risk for developing T2D.
Health self-perception is associated with life-styles and comorbidities and its effect on mortality is confounded by age. A population based study.
Front Med (Lausanne)
November 2022
Background: Health self-perception (HSP) is the individual and subjective concept that a person has of their state of health. Despite its simplicity, HSP is considered a valid and relevant indicator employed in epidemiological research and in professional practice as an overall measure of health.
Objectives: (1) To describe and analyze the associations between HSP and demographic variables, lifestyle and diseases prevalent in a population and (2) to investigate the relationship between HSP and mortality.
Aims: This study aimed to determine the effect of aging on glucose profiles in a population without diabetes.
Methods: We investigated the evolution of glucose profiles in an adult population without diabetes using continuous glucose monitoring (CGM) in two periods separated by 5 years. Anthropometrics, laboratory tests (HbA1c, fasting blood glucose) and CGM data (mean glycemia level, coefficient of variation, time in range) were measured in both periods to study the change in values over time.
Article Synopsis
- The study involved 1,516 adults, with findings showing that a significant portion were identified as risk drinkers, especially among men.
- Results indicate that certain -glycan profiles effectively differentiate risk drinkers from non-risk drinkers, enhancing diagnostic accuracy, although sensitivity remains relatively low.
Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice.
Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults.
Methods: We conducted a cross-sectional study of 1472 adults with no known inflammatory disorders (44.
Background And Aim: To investigate the influence of common factors on serum immunoglobulin M (IgM) concentrations in adults, and clinical associations with high and low values.
Methods: We measured serum IgM levels using immunonephelometry in a random sample of 1510 individuals (aged 18-91 years, 44.7% male).
Article Synopsis
- Researchers developed and validated a new risk model, called Gal-COVID-19 scores, to predict COVID-19 severity, hospitalization, ICU admission, and mortality based on patient data.
- The study analyzed 10,454 COVID-19 confirmed patients in Galicia, Spain, using a logistic regression approach that took into account factors like age, gender, and chronic health conditions.
- The model showed strong predictive abilities, with AUC scores indicating good accuracy in assessing hospitalization (0.77), ICU admission (0.83), and mortality (0.89), potentially aiding clinicians in identifying high-risk patients.
Objective: The objective was to investigate glycemic variability indices in relation to demographic factors and common environmental lifestyles in a general adult population.
Methods: The A Estrada Glycation and Inflammation Study is a cross-sectional study covering 1516 participants selected by sampling of the population aged 18 years and over. A subsample of 622 individuals participated in the Glycation project, which included continuous glucose monitoring procedures.
Background: STOPP (screening tool of older persons' prescriptions)/START (screening tool to alert doctors to right treatment) criteria aim to identify potentially inappropriate medication (PIM) due to mis-, over- and under-prescription in older patients. Initially developed by Irish experts, their applicability has been demonstrated in primary health care (PHC).
Objective: To quantify and identify the most frequent PIM at PHC level using STOPP/START criteria.
Background: Cytokeratin-18 is an essential component of the cytoskeleton of epithelial cells (including hepatocytes). Serum concentrations of cytokeratin-18 (tissue polypeptide-specific antigen [TPS]) are used as a marker of epithelial neoplasms. Here, we investigated the potential interaction between alcohol and obesity in relation to serum TPS concentrations.
View Article and Find Full Text PDFBackground: Serum tryptase measurements are increasingly being used in clinical practice. However, there is a paucity of studies focused on factors that influence tryptase concentrations. We investigated the relationships between total tryptase concentrations and age, gender, atopy, alcohol consumption, smoking, and common metabolic abnormalities in adults.
View Article and Find Full Text PDFBackground: Serum gamma-glutamyl transferase (GGT) is a well-known marker of alcohol consumption and liver dysfunction. GGT is also associated with components of metabolic syndrome, cardiovascular risk factors and obstructive sleep apnea. In a population-based study, we investigated serum GGT levels in relation to markers of nocturnal hypoxemia, adjusting for potential confounders.
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