Publications by authors named "Carmen Elena Arias"
Differential cardiomyocyte transcriptomic remodeling during in vitro Trypanosoma cruzi infection using laboratory strains provides implications on pathogenic host responses.
Katherine-Sofia Candray-Medina Yu Nakagama Masamichi Ito Shun Nakagama Evariste Tshibangu-Kabamba Carmen-Elena Arias
Trop Med Health
December 2023
Article Synopsis
- Chagas disease can result in severe heart issues, and different strains of the parasite Trypanosoma cruzi affect the disease's progression and symptoms.
- Researchers studied the effects of various T. cruzi strains on heart cells (cardiomyocytes) to understand how they impact gene expression related to heart damage.
- Key findings indicate that T. cruzi infection elevates oxidative stress and activates specific biological pathways linked to heart cell growth and death, particularly in cells infected by Colombian/Y strains.
Background: Since the late twentieth century, Chagas disease gained global attention to suppress the vector burden as a main control strategy in endemic countries. In Central America, multi-national initiative successfully achieved significant reduction in the estimated disease prevalence as well as elimination of the region's principal vector species at the time in 2012. While the last decade has witnessed significant changes in ecosystem-such as urbanization and replacement of the main vector species-that can possibly affect the vector's habitation and residual transmission, the up-to-date vector burden in the region has not been evaluated thoroughly due to the cessation of active vector surveillance.
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