Remote-controlled delivery of CO via photoactive CO-releasing materials on a fiber optical device.

Although carbon monoxide (CO) delivery materials (CORMAs) have been generated, remote-controlled delivery with light-activated CORMAs at a local site has not been achieved. In this work, a fiber optic-based CO delivery system is described in which the photoactive and water insoluble CO releasing molecule (CORM) manganese(i) tricarbonyl [(OC)3Mn(μ3-SR)]4 (R = nPr, 1) has been non-covalently embedded into poly(l-lactide-co-d/l-lactide) and poly(methyl methacrylate) non-woven fabrics via the electrospinning technique. SEM images of the hybrid materials show a porous fiber morphology for both polymer supports.

Light-triggered CO release from nanoporous non-wovens.

The water insoluble and photoactive CO releasing molecule dimanganese decacarbonyl (CORM-1) has been non-covalently embedded into poly(l-lactide-co-d/l-lactide) fibers via electrospinning to enable bioavailability and water accessibility of CORM-1. SEM images of the resulting hybrid non-wovens reveal a nanoporous fiber morphology. Slight CO release from the CORM-1 in the electrospinning process induces nanoporosity.

Rhenium and 99m-technetium complexes of monosaccharide based tripodal triamines as potential radio imaging agents.

A synthetic pathway to new sugar containing tripodal triamines of the TAME type (1,1,1-tris(aminomethyl)ethane) is presented. The tripodal bromo substituted precursors Ac3Xyl-O-CH2C(CH2Br)3, Ac4Glc-O-CH2C(CH2Br)3 and Ac4Gal-O-CH2C(CH2Br)3 (2a-c) were obtained by glycosidation reaction of the fully acetylated glycopyranosides with pentaerythritol tribromide. Nucleophilic substitution to the corresponding azides with sodium azide and deprotection of the sugars, followed by hydrogenation reaction in the presence of PtO2 leads to the triamines Xyl-O-CH2C(CH2NH2)3, Glc-O-CH2C(CH2NH2)3 and Gal-O-CH2C(CH2NH2)3 (5a-c).