Publications by authors named "Carmen Al-Masri"
Transcription factor (TF) proteins regulate gene expression by binding to specific sites on the genome. In the facilitated diffusion model, an optimized search process is achieved by the TF alternating between 3D diffusion in the bulk and 1D diffusion along DNA. While undergoing 1D diffusion, the protein can switch from a search mode for fast diffusion along nonspecific DNA to a recognition mode for stable binding to specific DNA.
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- Protein kinases are key signaling proteins that help maintain cell balance, but when they malfunction, they can lead to various diseases, making them prime targets for drug development.
- Kinase activity can switch between active and inactive forms, which creates unique environments for targeted drug design; understanding these conformational states is crucial for creating effective kinase inhibitors.
- The study leverages AlphaFold2's ability to predict different kinase structures, discovering that it can model various conformations while also providing insights into their flexibility and enhancing drug discovery efforts.