Mapping the genetic features of T-ALL cases through simplified NGS approach.

Background: Despite the irruption of massive sequencing technologies in clinical routine, the genetic diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) continues to be based on traditional techniques. The integration of old and new technologies with diagnostic and prognostic purposes represents a major challenge.

Methods: A High-Throughput Sequencing (HTS) approach was applied to analyze the genetic landscape of two patients diagnosed with T-ALL and one early T cell precursor acute leukemia.

Basaloid carcinoma of the prostate gland. An unusual finding.

Objectives: Carcinoma with basaloid features, known as basaloid carcinoma of prostate, is an extremely rare tumor. We report the clinical, histological and immunohistochemical findings in a case of prostatic basaloid carcinoma.

Methods/results: A 68-year old man consulted with a two-year history of increasing urinary outflow obstruction that developed into acute urinary retention.