Publications by authors named "Carmem Oliveira"
Objective: To analysis the epidemiological scenery of the congenital syphilis (CS) in Brazil employing spatial analysis techniques.
Design: Ecological study.
Settings: This study was conducted in Brazil SAMPLE: A total of 151 601 CS cases notified to the Diseases and Notification Information System from 2007 to 2018 from children aged 0-23 months and born from mothers living in Brazil were included in this study.
Comparison of plasma and oral fluid concentrations of mycophenolic acid and its glucuronide metabolite by LC-MS in kidney transplant patients.
Eur J Clin Pharmacol
April 2019
Purpose: Mycophenolic acid is one of the most used immunosuppressive drugs in solid organ transplant treatments in the world. Developing a highly sensitive analytical method to analyse the drug and its metabolites in oral fluid and plasma is important to evaluate the possibility of using oral fluid as a biological matrix in therapeutic drug monitoring, instead of plasma.
Method: The liquid chromatography coupled to mass spectrometry (LC-MS) method was developed and validated for determining mycophenolic acid (MPA) and its glucuronide metabolite (MPAG) in oral fluid and plasma, with both matrices presenting a detection limit of 1 ng/mL for MPA and 5 ng/mL for MPAG.
Molecular characterisation of newly identified HIV-1 infections in Curitiba, Brazil: preponderance of clade C among males with recent infections.
Mem Inst Oswaldo Cruz
December 2008
As in many areas of Brazil, the AIDS epidemic in Curitiba is relatively stable, but surveillance is important to support public policy. The molecular characteristics of HIV may be instrumental for monitoring epidemic trends. We evaluated plasma HIV-1 RNA (n = 37) from 38 cases presenting with positive serology, who were among 820 consenting volunteers visiting the downtown counselling and serology testing centre.
View Article and Find Full Text PDF[Prevalence and factors associated with vitamin A deficiency in preschool children from Teresina, Piauí, Brazil].
Cad Saude Publica
September 2006
Article Synopsis
- Vitamin A deficiency is a significant health issue among preschool children in Northeast Brazil, particularly in Teresina, Piauí, with a prevalence of 15.4%.
- The study analyzed 631 children aged 36 to 83 months, measuring serum retinol levels and evaluating factors such as demographics and socioeconomic status.
- Factors like age, income, maternal schooling, and vitamin A supplementation showed positive correlations with higher retinol levels, indicating the need for effective public health strategies to address this deficiency in the region.
Evaluation of renal enzymuria and cellular excretion as an marker of acute nephrotoxicity due to an overdose of paracetamol in Wistar rats.
Clin Chim Acta
November 2006
Introduction: The present study was conducted to determine whether the urinary levels of excreted enzymes, gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate (AST) and alanine aminotransferases (ALT), can efficiently indicate, within 24 h, an acute nephrotoxicity due to an overdose of paracetamol (PAR).
Methods: A baseline urine was collected from the experimental group. Thereafter, blood collected from the orbital sinus (1.