Publications by authors named "Carmela Ferri"
Article Synopsis
- - Recent research indicates that miR-423-5p plays a significant role in regulating the growth and spread of prostate cancer cells, both in laboratory settings and in living organisms, by affecting protein expression.
- - Proteomic analysis revealed 63 proteins that were differently expressed in prostate cancer cells with increased levels of miR-423-5p, leading to changes in metabolic processes like glycolysis and amino acid metabolism, as well as influences on immune response and transcriptional activity.
- - The study also identified seven key proteins linked to miR-423-5p that affect patient survival rates, highlighting the potential of miR-423-5p to drive metabolic changes and impact various tumor-related processes in prostate cancer. *
MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer.
J Exp Clin Cancer Res
January 2022
Article Synopsis
- - The long non-coding RNA MALAT1 is linked to worse outcomes in prostate cancer (PCa) and interacts with microRNAs, but its exact functions and regulation are not fully understood.
- - Research showed that higher MALAT1 levels correspond with more aggressive cancer features, including high Gleason grade and metastasis, and that miR-423-5p can inhibit MALAT1's effects on cancer cell growth and movement.
- - The study provides evidence that targeting the MALAT1/miR-423-5p relationship could be a potential therapeutic strategy in PCa by increasing survival rates and reducing metastatic behavior.
miR-125b, ubiquitously expressed and frequently dysregulated in several tumors, has gained special interest in the field of cancer research, displaying either oncogenic or oncosuppressor potential based on tumor type. We have previously demonstrated its tumor-suppressive role in multiple myeloma (MM), but the analysis of molecular mechanisms needs additional investigation. The purpose of this study was to explore the effects of miR-125b and its chemically modified analogs in modulating cell viability and cancer-associated molecular pathways, also focusing on the functional aspects of stress adaptation (autophagy and senescence), as well as programmed cell death (apoptosis).
View Article and Find Full Text PDFMicroRNAs (miRNAs) are endogenous non-coding RNAs of about twenty-two nucleotides that regulate gene expression through post-transcriptional control. The purpose of the present study was to identify and describe the salivary miRNAs in cleft lip and palate (CLP) patients comparing them with a control healthy group. Twelve patients (mean age 11.
View Article and Find Full Text PDFSorafenib is an antitumor drug for treatment of advanced hepatocellular carcinoma (HCC). It acts as a multikinase inhibitor suppressing cell proliferation and angiogenesis. Human microRNA-125a-5p (miR-125a) is endowed with similar activities and is frequently downregulated in HCC.
View Article and Find Full Text PDF